EGFR controls IQGAP basolateral membrane localization and mitotic spindle orientation during epithelial morphogenesis

Bañón-Rodríguez I, Gálvez-Santisteban M, Vergarajáuregui S, Bosch M, Borreguero-Pascual A, Martin-Belmonte F.

EMBO J. 2014. 


M Auzan, M Bornens, F Martin-Belmonte, AE Rodriguez-Fraticelli, J Young. (2013)

WO Patent 2,013,014,164

Methods for Analysis of Apical Lumen Trafficking Using Micropatterned 3D Systems.

Rodríguez-Fraticelli AE, Martín-Belmonte F.

Methods Cell Biol. 2013;118:105-23. doi: 10.1016/B978-0-12-417164-0.00007-0.

KIF16B delivers for transcytosis.

Rodríguez-Fraticelli AE, Galvez-Santisteban M, Martin-Belmonte F.

EMBO J. 2013 Jul 31;32(15):2093-5. doi: 10.1038/emboj.2013.153. Epub 2013 Jun 28.

Crossroads of Wnt and Hippo in epithelial tissues.

Bernascone I, Martin-Belmonte F.

Trends Cell Biol. 2013 Aug;23(8):380-9. doi: 10.1016/j.tcb.2013.03.007. Epub 2013 Apr 20.

Mechanical control of epithelial lumen formation

Rodríguez-Fraticelli AE, Martín-Belmonte F.

Small GTPases. 2013 Apr-Jun;4(2):136-40. doi: 10.4161/sgtp.24303. Epub 2013 Mar 19.

Cell confinement controls lumen initiation and centrosome positioning during epithelial morphogenesis.

Rodríguez-Fraticelli AE, Auzan MA, Alonso MA, Bornens M, Martín-Belmonte F. J Cell Biol 2012.

Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells.

Gálvez-Santisteban M, Rodriguez-Fraticelli AE, Bryant DM, Vergarajauregui S, Yasuda T, Bañón-Rodríguez I, Bernascone I, Datta A, Spivak N, Young K, Slim CL, Brakeman PR, Fukuda M, Mostov KE, Martín-Belmonte F.

Nat Cell Biol. 2012 Jul 22;14(8):838-49. doi: 10.1038/ncb2541. Epub 2012 Jul 22.

Epithelial cell polarity, stem cells and cancer.

Martin-Belmonte F, Perez-Moreno M.

Nat Rev Cancer. 2011 Dec 15;12(1):23-38.

Divide and polarize: recent advances in the molecular mechanism regulating epithelial tubulogenesis.

Rodríguez-Fraticelli AE, Gálvez-Santisteban M, Martín-Belmonte F.

Curr Opin Cell Biol. 2011 Oct;23(5):638-46.

A molecular network for de novo generation of the apical surface and lumen.

Bryant DM, Datta A, Rodriguez-Fraticelli A, Peränen J, Martin-Belmonte F, Mostov K

Nat Cell Biol. 2010 Nov;12(11):1035-45.

The formin INF2 regulates basolateral-to-apical transcytosis and lumen formation in association with Cdc42 and MAL2

Madrid R, Aranda JF, Rodríguez-Fraticelli AE, Ventimiglia L, Andrés-Delgado L, Shehata M, Fanayan S, Shahheydari H, Gómez S, Jiménez A, Martín-Belmonte F, Byrne JA, Alonso MA.

Dev Cell. 2010 May 18;18(5):814-27.

The Cdc42-GEF Intersectin 2 Controls Mitotic Spindle Orientation to Form the Lumen during Epithelial Morphogenesis

Rodríguez-Fraticelli AE, Vergarajauregui S, Eastburn D, Datta A, Alonso MA, Mostov K, Martín-Belmonte F

J Cell Biol. 2010 May 17;189(4):725-38.

Chapter 3: acquisition of membrane polarity in epithelial tube formation patterns, signaling pathways, molecular mechanisms, and disease.

Martín-Belmonte F, Rodríguez-Fraticelli AE.

Int Rev Cell Mol Biol. 2009;274:129-82. Review

Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis.

Martín-Belmonte F, Yu W, Rodríguez-Fraticelli AE, Ewald AJ, Werb Z, Alonso MA, Mostov K.

Curr Biol. 2008 Apr 8;18(7):507-13. Erratum in: Curr Biol. 2008 Jul 8;18(13):1016. Curr Biol. 2008 Apr 22;18(8):630.

Regulation of cell polarity during epithelial morphogenesis.

Martin-Belmonte F, Mostov K.

Curr Opin Cell Biol. 2008 Apr;20(2):227-34. Epub 2008 Feb 20. Review.

Phosphoinositides control epithelial development.

Martin-Belmonte F, Mostov K.

Cell Cycle. 2007 Aug 15;6(16):1957-61. Epub 2007 Jun 12. Review.

PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.

Martin-Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, Mostov K.

Cell. 2007 Jan 26;128(2):383-97.

Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells.

Gassama-Diagne A, Yu W, ter Beest M, Martin-Belmonte F, Kierbel A, Engel J, Mostov K.

Nat Cell Biol. 2006 Sep;8(9):963-70. Epub 2006 Aug 20. Erratum in: Nat Cell Biol. 2006 Oct;8(10):1178.

Developmental biology: the hole picture.

Mostov K, Martin-Belmonte F.

Nature. 2006 Jul 27;442(7101):363-4.


Publications & patents


“EGFR controls IQGAP and mitotic spindle orientation”, our newest paper is accepted on The EMBO Journal 2014!!!

“The findings presented here describe a new molecular mechanism involved in mitotic spindle orientation that drives the formation of the central lumen during epithelial morphogenesis.” 







2008 & before